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KMID : 0369819800100010113
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Jorunal of Korean Pharmaceutical Sciences
1980 Volume.10 No. 1 p.113 ~ p.123
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Hepatic Drug Clearance of Animal in Disease States Ⅰ ; Hepato - biliary Transport of Bromphenol Blue in Acute CCl4 Intoxicated Rabbits
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우종학/Woo CH
김신근/이민화/한건/Kim SK/Lee MH/Han K
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Abstract
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Bromphenol blue (BPB) was studied with rabbits in normal and disease states to understand the basic principles of hepato-biliary transport process, and the effect of disease states on the drug disposition. The time course of plasma concentration and of biliary excretion was studied in normal and CCl4 intoxicated rabbits. A conspicuous retention of BPB clearance from the plasma was observed, and the slope of the first-phase of plasma curve was decreased in the intoxicated rabbits. The shape of biliary excretion was same in normal and intoxicated states, but the amount of BPB excreted into bile in the intoxicated states was much smaller than in normal states. A relationship was found which enables one to predict the pattern of uptake of BPB by the liver, and the pattern of excretion into the bile in normal states, but was not in CCl4 intoxicated states. It may be that the application of this experiments would extend the effect of disease states on the drug disposition.
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KEYWORD
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